How To Use Iodine For Teeth

Information technology looks like 2020 is bringing the Canadian dental profession a gift, in the new selection of molecular iodine (I2) products from ioTech International. These products, surpass all of the existing gold standard disinfectants. Coming out of the gate, these products appear to exist game changers in antimicrobial chemical science. Dr. Gordon Christenson named ioRinse the "Best in Grade" antimicrobial amanuensis in Clinicians Written report for 2019. This technological breakthrough appears to have unlimited indications in medical, dental, agricultural and veterinary fields. To peak it off, I2 is an essential chemical element, natural, organic and safe for chronic use and information technology is being priced with the most affordable of all the antimicrobials.

History of Iodine Use
The recorded employ of iodine in medicine, dates dorsum to 5000 BC when seaweed and body of water sponges were used to compress goiters. Lugol'south iodine was introduced in 1829, tincture of iodine in 1908 and finally povidone iodine PVP-I in 1955 (brand name: Betadine). ioTech'due south patented molecular iodine products starting time surfaced in 2017 after several years of research and development to make iodine soluble and stable in aqueous solutions (Fig. 1). Betadine has 31,600 ppm of total iodine but just three ppm of molecular iodine; Iotech has less than 1000 ppm of total iodine just up to 600 ppm are actually molecular iodine. Since it is Just the molecular iodine that is a biocidal species of iodine, all the other species in Betadine or Povidone Iodine (PVP-I) contribute to staining or toxicity but DO NOT impale microbes (Figs. 1 & 2).

Fig. 1

Fig. ii

Povidine Iodine vs. Molecular Iodine
Kickoff, let's distinguish betwixt PVP-I and I2 then that we ameliorate understand these very like sounding, simply very different acting, germicidal agents. PVP-I is an aqueous solution of several different species of iodine (including iodide, iodate, triiodide, hypo-iodous acrid and molecular iodine). The iodine in PVP-I is bound to a large organic molecule, polyvinylpyrrolidone which, being highly soluble in water, carries the different iodine species, which have varying degrees of solubility, into solution forth with it. 10% PVP-I (common brand: Betadine) is used in hospitals, medical and dental offices worldwide. Information technology contains over 30,000 ppm of total iodine. The iodine species present in the to the lowest degree amount is I2 which is present at only 1-iii ppm1. All of the other species of iodine present contribute to staining, toxicity and irritation, but are not biocidal. Out of the over thirty,000 ppm of total iodine, the 1-iii ppm of I2 accounts for all of the antimicrobial action of PVP.

ioTech International, a Florida-based antimicrobial company, has developed and patented stable aqueous formulations of I2 which contain over 100 times the available I2 (compared to PVP-I) while limiting the other non-bioactive iodine species from 30,000ppm to just a few hundred ppm (Fig. 1). This dramatically increases efficacy while drastically minimizing overall toxicity. The need for polyvinylpyrrolidone is likewise eliminated in these formulations. ioTech'due south I2 formulations are essentially clear and practice not stain compared to PVP-I, even at x times the strength of PVP-I (Fig. 2).

Molecular iodine vs the aureate standard antimicrobials
In comparing the efficacy of PVP-I to chlorhexidine gluconate (CHX) confronting 6 periodontal bacteria (Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Fusobacterium nucleatum, Tannerella forsythensis, Prevotella intermedia and Streptococcus anginosus), Nakagawa, et al. adamant that PVP-I reduced all bacterial strains to below detectable limits within 15 seconds. Past contrast, there were more than than i,000 viable colonies remaining sixty seconds following treatment with CHX3.

ChloraPrep, a leading pre-operative surgical skin prep containing 2 germicidal agents, two.0% CHX and 70% isopropyl alcohol, required four times longer to accomplish a 4.0 log kill of Aspergillus brasiliensis (a highly resilient mucus) than a 300 ppm solution of I2 alone. PVP-I was completely ineffective confronting Aspergillus brasiliensis later 30 minutes but the fungus was completely inactivated within one-minute by I2. Similarly, Staph aureus was completely inactivated by an I2 formulation within 30 seconds but required v minutes for PVP-I to achieve the same upshot.

Several studies have demonstrated the ability of iodine to inactivate Strep mutans and to inhibit caries. A 25ppm I2 rima oris rinse completely inactivated Rhinovirus (a resilient, non-enveloped virus largely responsible for Upper Respiratory Infections (URIs) in 30 seconds, where CHX Oral Rinse, Listerine, Telescopic and Colgate Total mouthwashes were completely ineffective.8 An I2 pre-procedural rima oris rinse for patients is a far better choice to inactivate aerosolized bacteria and viruses than currently available mouthwashes. A recent study conducted at the Department of Periodontology, Tokyo Dental School ended that at a 30 second contact fourth dimension, iodine was effective in inactivating the bacteria in periodontal biofilms.9 A joint study conducted by the departments of periodontology at three European dental schools found that the persistent effect of iodine on subgingival microbial flora was far greater for iodine than for CHX (31 days vs 7 days).10

Fig. 3

I2 is chop-chop effective confronting viruses, bacteria (both Gram negative and Gram positive), fungi and spores. In ane study of hospital-level surface disinfectants, an ioTech I2 formulation inactivated major pathogens responsible for Hospital Acquired Infections 7 times faster than the fastest acting of 29 EPA-registered hospital disinfectants from major U.S. manufacturers. In some other report, an I2 conception inactivated a broad range of pathogens in one application inside one minute that required Clorox Disinfectant Spray and Lysol Disinfectant Spray x minutes and multiple applications to achieve.

A key benefit of iodine formulations is that, unlike CHX and other antimicrobial agents, iodine does not induce resistance evolution in targeted microorganisms.12 The substantivity (ongoing rest effect) of iodine for upwardly to 72 hours is also well documented.

Molecular iodine stands up to comparison to the gold standard of care with flight colours. Figure 4 shows a comparison of molecular iodine against both Betadine (PVP-1) and CHX. Notation the molecular iodine shows best because information technology doesn't allow for bacterial resistance, has the boldest spectrum of activity (including rhinovirus), has the almost rapid speed of kill, the ability to use information technology long term without staining, no calculus formation or bad taste problems. Compared to the CHX, it was the safest with no known side effects, not combustible like CHX, and no history of bug like affecting the microbiome adversely with chronic apply, carcinogenicity, mucosal irritation, staining, altered sense of taste sensation, occasional bacterial contamination, or rare but reported anaphylactic shock, which have all been associated with CHX. Chlorhexidine is also often augmented with lxx% isopropyl alcohol to heighten its bacterial efficacy which is not necessary with I2. The molecular iodine also demonstrated the longest lasting elapsing of effect.

Fig. iv

Bioscience Laboratories (Bozeman, Montana 2016-2019) did a comparison of molecular iodine (I2) to CHX oral rinse (Fig. five). The ii were compared for efficacy against: 1) Fusobaterium nucleatum (periodontal), Streptococcus mutants (dental decay), and Rhinovirus (upper respiratory infections) and man Coronavirus. Molecular iodine came out alee of CHX for all three cases. In fact, it was the just one that killed the Rhinovirus and information technology was more than effective against ariogenic and periodontal bacteria, and Coronavirus, taking only 15 seconds to completely inactivate all of these pathogens. In some other BioScience Laboratories report, comparing the virucidal effect of several oral rinses, a 25 ppm I2 oral rinse completely inactivated Rhinovirus and Coronavirus in 30 seconds, where Listerine, Telescopic and Colgate were ineffective.

Fig. v

Validation for the use of iodine in the dental arena
The American Eye Association, the American Dental Association and others recommend rinsing periodontal sites with povidone iodine. Professor Jorgen Slots at Herman Ostrow Dental School of Southern California has cited povidone iodine as having all the characteristics for becoming a outset choice in the treatment and prevention of periodontal disease. With the new I2 products being so much more efficacious than povidone iodine and more than efficacious and safer than Chlorhexidine Gluconate and with none of the drawbacks of either, information technology'south hard to imagine that these products would not be mainstream in dental offices in the very near future.

Fig. 6

Besides being apace constructive confronting periodontal and cariogenic pathogens, molecular iodine penetrates oral biofilms and it destroys bacteria that produce volatile sulfur compounds, making it a not bad product for halitosis besides. Reports show that an increase in the concentration of the molecular iodine used will consequence in a corresponding greater biocidal action, allowing for titration of the concentration depending on the need (Fig. 7).

Fig. 7

Suggested indications for use of molecular iodine in dentistry
Periodontal disease (affects 75-80% of developed population), molar disuse (affects 96% of Americans), all topically treated oral infections such equally fungal, viral or bacterial, oral mucositis, thrush, herpes sores, herpetic ulcers, pre and post procedural rinses, in-office subgingival irrigation, and daily at-abode use, including employ in units such as water irrigation devices or tray application as a gel. Caries management protocols might include I2 and a combination of xylitol/erythrotol (25%) with I2 is showing promise; endodontic indications are as an end irrigant, file lubricant, ultrasonic canal solution, antimicrobial sealer+++. A 2nd commodity volition follow with indications and methods of utilise of I2 in the dental office.

Molecular iodine's new breakthrough engineering advantages
Other products are contra-indicated for chronic utilise. Molecular iodine is an essential nutrient and is safe for chronic use. It is used in very depression concentrations and is strongly effective against leaner, fungi, viruses and even spores. This production is articulate and not-staining. It is more than constructive and safer than chlorhexidine gluconate, povidone iodine, peroxide, alcohol or whatever other currently available mouth rinse. It is the most effective and efficient product at reducing both periodontal and cariogenic pathogens without inducing microbial resistance. This product is natural and organic and tin can be delivered for home use, so chair time is not required to treat with it. Other advantages include:

Broad spectrum of impale
Rapid speed of kill
Lack of microbial resistance
Excellent safety and allergy profile
Substantivity
Ease of apply
Affordable to patients
No deleterious side effects
Indicated for chronic utilise

Iii oral care products are now existence marketed to the dental profession. A concentrated aqueous solution, a ready to use aqueous solution and a gel (Fig. 8).

Fig. 8

Any inquiries about the products or for purchase tin can be made by contacting ioTech International, https://iotechinternational.com. 1 bold periodontist from Baltimore Dental, who beta tested ioTech rinses in his office has suggested that, "ioTech products will likely exist as therapeutic equally scaling and root planing in the treatment and management of periodontal disease". This is hard to imagine but if we tin control the biofilm and microflora intraorally in a safe fashion, we solve the majority of microbial oral diseases, specially related to periodontal and carious pathology.

This safety, effective, natural and organic antimicrobial is showing real hope to becoming the chemotherapeutic/preventative agent of selection in the dental profession. We look forward to further research and validation of new I2 products in the future.

Oral Health welcomes this original article.

Disclaimer: Dr. Herb Moskowitz is the Chairman and Co-Founder of ioTech International and Co-Author of ioTech's patents; Dr. Janice Goodman has a financial interest in the company being profiled.

About the Author

Herb Moskowitz has xl years of healthcare experience, including 25 years in the clinical practice of dentistry. He can be reached at herbmoskowitz@iotechinternational.com.

Janice Goodman practices general dentistry in downtown Toronto and is a fellow member of the Editorial Board of Oral Health Dental Journal. She tin can be reached at dentistryinto@gmail.com.